Luxury skincare editorial collage

Want
Skin
That
Feels
Like
You
Again?

Discover the benefits of Biostimulator®,
the first proven regenerative
biostimulator1-5

Biostimulator
BIOSTIMULATOR ADRESSES SIGNS OF SKIN AGING6-8
BIOSTIMULATOR STIMULATES THE PRODUCTION OF YOUR OWN COLLAGEN
AND ELASTIN FROM WITHIN2,10,12
COLLAGEN IS THE MOST COMMON PROTEIN IN THE BODY AND ACTS AS THE SKIN’S SUPPORT STRUCTURE WHILE ELASTIN PROVIDES STRETCH, REBOUND AND ELASTICITY
TO THE SKIN9,10
WHAT IS THE UNIVERSAL CAUSE OF SKIN AGING?
From the age of 20, 1% of collagen is lost per year so skin feels
less firm as our body’s collagen declines naturally.6
Intrinsic aging occurs naturally and it is accelerated by extrinsic aging caused by external factors such as sunlight exposure, pollution and
lifestyle choices. As we age, essential
components of the skin degrade over time.6,8,11
Changes over time
AGE 35
Up to 15% of collagen loss6
AGE 45
Up to 25% of collagen loss6
AGE 55
Up to 35% of collagen loss6
FIRMNESS
ELASTICITY
STRUCTURE
TEST THE FIRMNESS OF YOUR SKIN
THREE SIMPLE WAYS TO CHECK YOUR SKIN’S FIRMNESS
PINCH
Lightly pinch your skin –
Does your skin stretch and does it feel thin?
PUSH
Lightly push your cheek up – Does your skin drape?
SMILE
Look in the mirror and smile –
Can you see fine lines and wrinkles around the cheek?
GABRIELA
Before
6 months
12 months

Actual patient, treated over 2 sessions, 1 vial per session; 9 weeks between sessions. Individual results may vary

UNLOCK THE REGENERATIVE
POWER OF YOUR SKIN3,12-14
A UNIQUE TREATMENT THAT HELPS STIMULATE
YOUR OWN COLLAGEN AND ELASTIN2,10,12
Biostimulator is the first proven regenerative biostimulator made from poly-L-lactic acid (PLLA-SCATM). PLLA-SCATM microparticles can work across all 3 skin layers, stimulating
your own collagen and elastin production.2,3,10,14-16
BIOSTIMULATOR STIMULATES YOUR OWN COLLAGEN AND ELASTIN PRODUCTION FOR FIRMER, RADIANT,
YOUTHFUL-LOOKING SKIN13,18
BIOSTIMULATOR
is injected deep into the skin17
BUILD
Production of new collagen and elastin12,17
REJUVENATE
Leading to natural-looking, rejuvenated skin for more than 2 years16
STIMULATE
Biodegradable PLLA-SCATM stimulates
your own collagen and elastin production before breaking down12,17
RESTORE
After just 1 month, your skin’s structure
starts to be restored13,16,19
CHLOE, 39
Having rejuvenated skin just made me feel happier [and] younger
“
“
CHRISTIAN, 44
As time went on,
it got harder to grab a piece of skin as it got firmer
“
“
SKIN THAT
FeelS lIKe You AGAIN
IMAN
ROB
Before
6 months
12 months

Actual patient, treated over 2 sessions, 1 vial per session; 6 weeks between sessions. Individual results may vary

Before
6 months
12 months

Actual patient, treated over 2 sessions; 1 vial per session; 9 weeks between sessions. Individual results may vary

References background

References:

1. Biostimulator. Instructions for Use EU 2020.

2. Widgerow, A et al. Poster presented at IMCAS World Congress. 01-03 February 2024. Paris, France.

3. Huth, S et al. J Drugs Dermatol. 2024 Apr 1;23(4):285-288.

4. PLACEHOLDER. Date on File (MA-60875).

5. Zhang Y, et al. Regen Biomater 2021;8(5):rbab042.

6. Shuster S, et al. Br J Dermatol. 1975;93:639-643.

7. Vleggaar D, Fitzgerald R. J Drugs Dermatol. 2008;7(3):209-220.

8. Zhang S, Duan E. Cell Transplant. 2018;27(5):729-738.

9. Rittie L, Fisher GJ. Cold Spring Harb Perspect Med. 2015;5:a015370.

10. Goldberg D, et al. Dermatol Surg. 2013;39(6):915-922.

11. Hexsel D, et al. Dermatol Surg. 2020;46(8):1122-1124.

12. Fitzgerald R, et al. Aesthet Surg J. 2018;38(suppl_1):S13-S17.

13. Fabi S, et al. Poster presented at IMCAS World Congress. 26-28 January 2023. Paris, France.

14. Oh S, et al. Antioxidants (Basel). 2023;12(6):1204.

15. Asius J, et al. Inventors. US patent US 7,731,758 B2.2010.

16. Narins RS et al. J Am Acad Dermatol. 2010;62(3):448-462.

17. Marchado Filho CD, et al. Surg Cosmet Dermatol. 2013;5(4):345-350.

18. PLACEHOLDER. A patient's guide to treatment with BIOSTIMULATOR. 2021.

19. Brandt FS, et al. Aesthet Surg J. 2011;31(5):521-528.

20. Bohnert K, et al. Plast Reconstr Surg. 2019;45(5):718-724.

21. Brown SA, et al. Plast Reconstr Surg. 2011;127:1684.

22. PLACEHOLDER. Data on file (MA-48331).

Biostimulator

© 2024 PLACEHOLDER

All rights reserved. All materials within this document are protected by copyright law and may not be reproduced, distributed, displayed, or published without the prior, express written permission of PLACEHOLDER. Biostimulator, PLLA-SCA and PLACEHOLDER are trademarks owned by PLACEHOLDER Holding S.A.

GL-SCU-2400149 | OCTOBER 2024